| Gender: | Women's |
| Year: | 2021 |
| Dates: | May 14–30, 2021 |
| Teams: | 29 |
| Finalsfield: | Johnny Unitas Stadium |
| Finalscity: | Towson, MD |
| Champions: | Boston College |
| Titlecount: | 1st |
| Runnerup: | Syracuse |
| Gamecount: | 3rd |
| Semifinal1: | North Carolina |
| Finalfourcount1: | 11th |
| Semifinal2: | Northwestern |
| Finalfourcount2: | 12th |
| Coach: | Acacia Walker-Weinstein |
| Coachcount: | 1st |
| Mop: | Charlotte North |
| Mopteam: | Boston College |
The 2021 NCAA Division I Women's Lacrosse Championship was the 39th annual single-elimination tournament to determine the national champion of Division I NCAA women's college lacrosse. The semifinal and championship rounds were played at Johnny Unitas Stadium in Towson, MD from May 28–30, 2021.[1] All other rounds were played at campus sites, usually at the home field of the higher-seeded team, from May 14–22. This marked the return of the tournament after 2020 was cancelled due to the COVID-19 pandemic.
All NCAA Division I women's lacrosse programs were eligible for this championship, and a total of 29 teams were invited to participate. 15 teams qualified automatically by winning their conference tournaments while the remaining 14 teams qualified at-large based on their regular season records.[2]
| Seed | School | Conference | Berth Type | RPI[3] | Record |
|---|---|---|---|---|---|
| 1 | North Carolina | ACC | Automatic | 1 | 18–0 |
| 2 | Northwestern | Big Ten | Automatic | 7 | 13–0 |
| 3 | Syracuse | ACC | At-large | 2 | 14–3 |
| 4 | Boston College | ACC | At-large | 3 | 13–3 |
| 5 | Notre Dame | ACC | At-large | 6 | 9–6 |
| 6 | Florida | American | Automatic | 10 | 16–2 |
| 7 | Duke | ACC | At-large | 21 | 9–7 |
| 8 | Stony Brook | America East | Automatic | 5 | 14–2 |
| UConn | Big East | At-large | 30 | 12–6 | |
| Denver | Big East | Automatic | 13 | 14–3 | |
| Drexel | CAA | At-large | 4 | 13–2 | |
| Fairfield | MAAC | Automatic | 14 | 13–1 | |
| High Point | Big South | Automatic | 38 | 10–7 | |
| Hofstra | CAA | At-large | 11 | 6–6 | |
| Jacksonville | ASUN | Automatic | 17 | 11–1 | |
| James Madison | CAA | Automatic | 15 | 11–4 | |
| Johns Hopkins | Big Ten | At-large | 46 | 8–6 | |
| Loyola (MD) | Patriot | Automatic | 8 | 11–2 | |
| Maryland | Big Ten | At-large | 36 | 9–6 | |
| Massachusetts | Atlantic 10 | Automatic | 12 | 15–2 | |
| Mercer | SoCon | Automatic | 45 | 7–7 | |
| Mount St. Mary's | NEC | Automatic | 16 | 14–2 | |
| Robert Morris | MAC | Automatic | 39 | 14–2 | |
| Rutgers | Big Ten | At-large | 54 | 6–8 | |
| Stanford | Pac-12 | Automatic | 9 | 11–0 | |
| Temple | American | At-large | 18 | 12–5 | |
| Towson | CAA | At-large | 23 | 9–8 | |
| Vanderbilt | American | At-large | 19 | 12–6 | |
| Virginia | ACC | At-large | 25 | 8–8 | |
Games on Conference Sports Networks (BTN & BTN+) or ESPN3 for First & Second Rounds. Semifinals on ESPNews & Finals on ESPNU.[4]
Copied content from 2019 NCAA Division I Women's Lacrosse Championship; see that page's history for attribution