See main article: article and 2021 Mutua Madrid Open.
Barbora Krejčíková and Kateřina Siniaková defeated Gabriela Dabrowski and Demi Schuurs in the final, 6–4, 6–3 to win the women's doubles tennis title at the 2021 Madrid Open. It marked the duo's seventh career WTA Tour doubles title together, as well as Krejčíková's eighth individual doubles title and Siniaková's 10th.[1] [2] [3]
Hsieh Su-wei and Barbora Strýcová were the reigning champions from when the tournament was last held in 2019,[4] but Strýcová did not return to compete due to her pregnancy.[5] Hsieh partnered Elise Mertens; they lost in the second round to Jeļena Ostapenko and Anastasia Pavlyuchenkova.[6] Despite the loss, Mertens usurped Hsieh for the WTA No. 1 doubles ranking.
The following pairs received wildcards into the doubles main draw:
The following pair received entry into the doubles main draw using a protected ranking:
Oksana Kalashnikova / 
Alla Kudryavtseva
Makoto Ninomiya / 
Yaroslava Shvedova Elena Vesnina / Vera ZvonarevaThe following pair received entry into the doubles draw as an alternate:
Tímea Babos / Veronika Kudermetova → replaced by Veronika Kudermetova / Anastasia Potapova
Ashleigh Barty / 
Jennifer Brady → replaced by Nao Hibino / 
Renata Voráčová
Aliona Bolsova / 
Danka Kovinić → replaced by 
Paula Kania-Choduń / Katarzyna Piter Anna Kalinskaya / 
Viktória Kužmová → replaced by Ekaterina Alexandrova / 
Yang Zhaoxuan Asia Muhammad / Jessica Pegula → replaced by Kaitlyn Christian / Sabrina Santamaria Elena Rybakina / Maria Sakkari → replaced by Petra Martić / Shelby Rogers
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