| Date: | 15–21 November |
| Edition: | 1st |
| Surface: | Clay |
| Venue: | Carrasco Lawn Tennis Club |
| Location: | Montevideo, Uruguay |
| Category: | WTA 125 |
| Prize Money: | $115,000 |
| Champs: |  Diane Parry |
| Champd: |  Irina Bara /  Ekaterine Gorgodze |
The 2021 Montevideo Open was a professional tennis tournament played on red clay courts in Montevideo. It was the first edition for the women that was also part of the 2021 WTA 125K series.[1] It took place at the Carrasco Lawn Tennis Club in Montevideo, Uruguay between November 8 and 21, 2021. The 2020 edition could not take place due to the COVID-19 pandemic.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Brazil | Beatriz Haddad Maia | 80 | 1 | |
 Hungary | Anna Bondár | 107 | 2 | |
| Hungary | Panna Udvardy | 116 | 3 | |
| Romania | Irina Bara | 133 | 4 | |
| France | Diane Parry | 149 | 5 | |
| Georgia | Ekaterine Gorgodze | 154 | 6 | |
 Argentina | Paula Ormaechea | 214 | 7 | |
| Brazil | Laura Pigossi | 218 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Marina Bulbarella Martina Capurro Taborda
Dasha Ivanova
Olivia Tjandramulia Gabriela Cé → replaced by Carolina Alves Grace Min → replaced by 
Ana Sofía Sánchez Laura Pigossi
Carol Zhao
Mayar Sherif → replaced by 
Marina Bassols Ribera
Anastasia Tikhonova → replaced by Elina Avanesyan Renata Zarazúa → replaced by 
Anna Sisková
Zhang Shuai → replaced by Bárbara Gatica| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Romania | Irina Bara | Georgia | Ekaterine Gorgodze | 158 | 1 | |
| Arianne Hartono | Australia | Olivia Tjandramulia | 373 | 2 | ||
| Hungary | Anna Bondár | Hungary | Panna Udvardy | 377 | 3 | |
| Argentina | María Lourdes Carlé | Brazil | Laura Pigossi | 408 | 4 |
The following pairs received wildcards into the doubles main draw:
See main article: 2021 Montevideo Open – Singles.
Diane Parry def. Panna Udvardy, 6–3, 6–2See main article: 2021 Montevideo Open – Doubles.
Irina Bara / Ekaterine Gorgodze def. Carolina Alves / Marina Bassols Ribera 6–4, 6–3