| Competition: | Midwest Premier League |
| Winners: | Milwaukee Bavarian SC (Western Conference) Detroit City U23 (Eastern Conference) |
| Matches: | 122 |
| Total Goals: | 450 |
| League Topscorer: | Jordan Walker (FC Diablos) (15 goals) |
| Biggest Home Win: | Milwaukee Bavarian SC 8-0 Union Dubuque (May 12) |
| Biggest Away Win: | LK St.Clair 0-8 Lansing Common (Jul 11) |
| Highest Scoring: | LK St.Clair 2-7 Detroit City U23 (Jul 14) |
| Nextseason: | 2022 |
| Dates: | April 17 - August 1 |
The 2021 Midwest Premier League season has been the first season of the Midwest Premier League.
The season have seen 20 founder teams divided in two divisions and the two toppers of each division have been crowned champions. Milwaukee Bavarian SC have won the West Division and Detroit City U23 topped the East Division.
| Team | City | Stadium | Founded |
|---|---|---|---|
| West Division | |||
| Berber City FC | Chicago, IL | Lions for Hope Sports Complex | 2013 |
| Cedar Rapids Inferno[1] | Fairfax, IA | Fairfax Sports & Park Complex | 2019 |
| Chicago Athletic FC | Bensenville, IL | Redmond Recreational Complex | |
| Chicago Mustangs | Crystal Lake, IL | MAC Athletic Complex | 2012 |
| DeKalb County United | DeKalb, IL | NIU Soccer and Track & Field Complex | 2017 |
| FC Diablos | Bloomington, IL | Tucci Stadium | 2019 |
| Edgewater Castle FC | Chicago, IL | CIBC Fire Pitch | 2017 |
| Milwaukee Bavarian SC | Glendale, WI | Heartland Value Fund Stadium | 1929 |
| RWB Adria | Chicago, IL | Hales Franciscan High School | 1959 |
| Rockford FC | Rockford, IL | Auburn High School | 2019 |
| Steel City FC | Joliet, IL | DuPage Medical Group Field | 2020 |
| Union Dubuque FC | Dubuque, IA | Dubuque Soccer Complex | 2017 |
| Team | City | Stadium | Founded | ||||
|---|---|---|---|---|---|---|---|
| East Division | |||||||
| BiH Grand Rapids | Grand Rapids, MI | Midwest United Complex | 2018 | ||||
| Detroit City FC U23 | Hamtramck, MI | Keyworth Stadium | 2020 | ||||
| Inter Detroit | Auburn Hills, MI | Evolution Sportsplex | 2017 | ||||
| Lansing Common FC | Lansing, MI | Eastern High School Stadium | 2020 | ||||
| Livonia City FC | Livonia, MI | Schoolcraft College | 2015 | ||||
| LK St. Clair | Mount Clemens, MI | Mount Clemens High School | 2017 | ||||
| Michigan Stars U23 | Washington Township, MI | Michigan Stars Sports Center | 1982 | ||||
| West Michigan Bearings | Byron Center, MI | South Christian High School | 2020 | ||||