| Date: | 18–24 October 2021 |
| Edition: | 9th |
| Surface: | Hard |
| Location: | Macon, Georgia, United States |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $80,000 |
| Champs: |  Madison Brengle |
| Champd: | Quinn Gleason / Catherine Harrison |
| Main Name: | Tennis Classic of Macon |
The 2021 Mercer Tennis Classic was a professional women's tennis tournament played on outdoor hard courts. It was the ninth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Macon, Georgia, United States between 18 and 24 October 2021.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Madison Brengle | 88 | 1 | ||
 Kazakhstan | Zarina Diyas | 108 | 2 | |
 Slovakia | Kristína Kučová | 112 | 3 | |
 Brazil | Beatriz Haddad Maia | 115 | 4 | |
 Mexico | Renata Zarazúa | 118 | 5 | |
 Australia | Maddison Inglis | 127 | 6 | |
 China | Wang Xiyu | 137 | 7 | |
 Canada | Rebecca Marino | 157 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry using a protected ranking:
The following players received entry from the qualifying draw:
Robin Anderson Hanna Chang Louisa Chirico Victoria Duval Allie Kiick Danielle Lao Whitney Osuigwe Alana SmithSee main article: 2021 Mercer Tennis Classic – Singles.
Madison Brengle def. Zarina Diyas, 6–4, 4–6, 6–4See main article: 2021 Mercer Tennis Classic – Doubles.
Quinn Gleason / Catherine Harrison def. Alycia Parks / Alana Smith, 6–2, 6–2