See main article: 2021 Meerbusch Challenger.
Andre Begemann and Florin Mergea were the defending champions[1] but only Begemann chose to defend his title, partnering Albano Olivetti. Begemann lost in the first round to Jesper de Jong and Bart Stevens.
Szymon Walków and Jan Zieliński won the title after defeating Dustin Brown and Robin Haase 6–3, 6–1 in the final.