| Date: | 9–15 August |
| Edition: | 8th |
| Surface: | Clay |
| Location: | Meerbusch, Germany |
| Champs: | Marcelo Tomás Barrios Vera |
| Champd: |  Szymon Walków / Jan Zieliński |
| Before Year: | 2019 |
The 2021 Meerbusch Challenger was a professional tennis tournament played on clay courts. It was the eighth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Meerbusch, Germany, between 9 and 15 August 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Daniel Altmaier | 120 | 1 | ||
 Bosnia and Herzegovina | Damir Džumhur | 121 | 2 | |
| Botic van de Zandschulp | 126 | 3 | ||
| Oscar Otte | 140 | 4 | ||
 Argentina | Juan Manuel Cerúndolo | 145 | 5 | |
 Czech Republic | Tomáš Macháč | 150 | 6 | |
 Slovakia | ||||
 India | Sumit Nagal | 159 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2021 Meerbusch Challenger – Singles.
Juan Manuel Cerúndolo 7–6(9–7), 6–3.See main article: 2021 Meerbusch Challenger – Doubles.
Szymon Walków / Jan Zieliński def. Dustin Brown / Robin Haase 6–3, 6–1.
