| Year: | 2021 |
| Team: | Louisville Cardinals |
| Sport: | Football |
| Conference: | Atlantic Coast Conference |
| Division: | Atlantic Division |
| Short Conf: | ACC |
| Record: | 6–7 |
| Conf Record: | 4–4 |
| Hc Year: | 3rd |
| Off Scheme: | Spread option |
| Def Coach: | Bryan Brown |
| Dc Year: | 3rd |
| Codef Coach1: | Cort Dennison |
| Codc1 Year: | 3rd |
| Def Scheme: | 4–2–5 |
| Stadium: | Cardinal Stadium |
| Bowl: | First Responder Bowl |
| Bowl Result: | L 28–31 vs. Air Force |
The 2021 Louisville Cardinals football team represented the University of Louisville during the 2021 NCAA Division I FBS football season. This was the team's third season under head coach Scott Satterfield. The Cardinals played their home games at Cardinal Stadium in Louisville, Kentucky, and competed as a member of the Atlantic Coast Conference (ACC).
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