See main article: article and 2021 Los Cabos Open.
Romain Arneodo and Hugo Nys were the reigning champions from when the tournament was last held in 2019,[1] but chose to play in Gstaad instead.
Hans Hach Verdugo and John Isner won the title, defeating Hunter Reese and Sem Verbeek in the final, 5–7, 6–2, [10–4].[2]