The 2021 Los Cabos Open (also known as the Mifel Open for sponsorship reasons) was an ATP tennis tournament played on outdoor hard court. It was the 5th edition of the tournament, and part of the ATP Tour 250 series of the 2021 ATP Tour. It took place in Los Cabos, Mexico from 19 July through 25 July 2021.[1]
See main article: 2021 Los Cabos Open – Singles.
Cameron Norrie def. 
Brandon Nakashima 6–2, 6–2.See main article: 2021 Los Cabos Open – Doubles.
Hans Hach Verdugo / John Isner def. Hunter Reese / Sem Verbeek 5–7, 6–2, [10–4].| Event | W | F | SF | QF | Round of 16 | Round of 32 | width=85 | Q | width=85 | Q2 | width=85 | Q1 |
| Singles | 250 | 150 | 90 | 45 | 20 | 0 | 12 | 6 | 0 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Doubles | 0 |
| Event | W | F | SF | QF | Round of 16 | Round of 32 | width=85 | Q2 | width=85 | Q1 |
| Singles | €58,705 | €42,095 | €29,965 | €19,975 | €12,840 | €7,730 | €3,775 | €1,960 | ||
| Doubles* | €21,920 | €15,690 | €10,340 | €6,720 | €3,940 |
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| United Kingdom | Cameron Norrie | 32 | 1 | |
| John Isner | 34 | 2 | ||
| Taylor Fritz | 40 | 3 | ||
| Sam Querrey | 68 | 4 | ||
 Australia | Jordan Thompson | 71 | 5 | |
| Steve Johnson | 83 | 6 | ||
 Italy | Andreas Seppi | 87 | 7 | |
| Mackenzie McDonald | 103 | 8 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
Elias Ymer
Ričardas Berankis → replaced by 
Jurij Rodionov Brandon Nakashima James Duckworth → replaced by 
Yasutaka Uchiyama
Daniel Elahi Galán → replaced by 
Emilio Gómez
Egor Gerasimov → replaced by 
Evgeny Donskoy Ilya Ivashka → replaced by Sebastian Ofner Sebastian Korda → replaced by Peter Gojowczyk
Adrian Mannarino → replaced by J. J. Wolf
Guido Pella → replaced by Alex Bolt| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| United Kingdom | Luke Bambridge | United Kingdom | Ken Skupski | 126 | 1 | |
 Israel | Jonathan Erlich | Mexico | Santiago González | 126 | 2 | |
 Pakistan | Aisam-ul-Haq Qureshi |  India | Divij Sharan | 135 | 3 | |
| Australia | Matthew Ebden | Australia | John-Patrick Smith | 145 | 4 |
The following pairs received wildcards into the doubles main draw:
Miguel Ángel Reyes-Varela → replaced by 
Harri Heliövaara / Miguel Ángel Reyes-Varela Harri Heliövaara → replaced by Sriram Balaji / Luca Margaroli Lloyd Glasspool / Cameron Norrie → replaced by Evgeny Donskoy / 
Illya Marchenko Matt Reid / Jordan Thompson → replaced by Alex Bolt / Jordan Thompson