| Liga 3 South Sumatra | |
| Year: | 2021 |
| Dates: | 8–21 December 2021 |
| Num Teams: | 15 |
| Defending Champions: | Muba United |
| Champions: | PS Palembang[1] |
| Count: | 2 |
| Runner-Up: | Persimuba Musi Banyuasin |
| Prevseason: | 2019 |
| Nextseason: | 2022 |
The 2021 Liga 3 South Sumatra was the third season of Liga 3 South Sumatra as a qualifying round for the national round of the 2021–22 Liga 3.[2]
Muba United were the defending champion.
There are 8 teams participated in the league this season.
| Team | Location | |
|---|---|---|
| Bhayangkara Sriwijaya | Palembang | |
| Palembang Sportivo | Palembang | |
| Persimuba Musi Banyuasin | Musi Banyuasin | |
| Persimura Musi Rawas | Musi Rawas | |
| Persipra Prabumulih | Prabumulih | |
| PS Banyuasin | Banyuasin | |
| PS Palembang | Palembang | |
| PSSL Bayung Lencir | Musi Banyuasin |
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