| Liga 3 Central Sulawesi | |
| Year: | 2021 |
| Dates: | 20 October[1] –18 November 2021 |
| Num Teams: | 17 |
| Defending Champions: | Pestu Touna |
| Champions: | Persipal Palu |
| Count: | 2 |
| Runner-Up: | Bandar Sulteng |
| Third: | Palu Putra |
| Fourth: | PSNB Nupa Bomba |
| Matches: | 70 |
| Goals: | 232 |
| Prevseason: | 2019 |
| Nextseason: | 2022 |
The 2021 Liga 3 Central Sulawesi will be the sixth season of Liga 3 Central Sulawesi as a qualifying round for the national round of the 2021–22 Liga 3.
Pestu Touna were the defending champion.
There are 17 teams participated in the league this season.
| Team | Location | |
|---|---|---|
| Bandar Sulteng | Palu | |
| Buol United | Buol Regency | |
| Celebest | Palu | |
| Garuda Yaksa | Donggala Regency | |
| Kramat Jaya | Palu | |
| Palu Putra | Palu | |
| Persbul Buol | Buol Regency | |
| Persido Donggala | Donggala Regency | |
| Persipal Palu | Palu | |
| Persipar Parigi | Parigi Moutong Regency | |
| Persipera Peling Raya | Banggai Islands Regency | |
| Persitimo Tinombo Moutong | Parigi Moutong | |
| Persito Tolitoli | Tolitoli Regency | |
| Pestu Touna | Tojo Una-Una Regency | |
| PS Tisswan | Donggala Regency | |
| PSNB Nupa Bomba | Donggala Regency | |
| Rajawali United | Morowali Regency |
All matches will held in Gawalise Stadium, Palu.