The 2021 Ladies Open Lausanne was a women's tennis tournament played on outdoor clay courts. It was the 28th edition of the Ladies Open Lausanne, and part of the 250 category of the 2021 WTA Tour. It took place at Tennis Club Stade-Lausanne in Lausanne, Switzerland, from 12 through 18 July 2021.[1]
See main article: 2021 Ladies Open Lausanne – Singles.
Clara Burel, 4–6, 7–6(7–5), 6–1This was Zidanšek's maiden WTA Tour singles title.
See main article: 2021 Ladies Open Lausanne – Doubles.
Ulrikke Eikeri / Valentini Grammatikopoulou, 6–3, 6–7(3–7), [10–5]| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Tamara Zidanšek | 47 | 1 | ||
| France | Fiona Ferro | 51 | 2 | |
| Jil Teichmann | 55 | 3 | ||
 Italy | Camila Giorgi | 62 | 4 | |
| France | Caroline Garcia | 76 | 5 | |
| Arantxa Rus | 84 | 6 | ||
| Italy | Jasmine Paolini | 88 | 7 | |
 Russian Federation | Anna Blinkova | 89 | 8 |
The following players received wildcards into the main draw:
The following player received entry using a protected ranking:
The following players received entry from the qualifying draw:
Sorana Cîrstea → replaced by 
Maryna Zanevska Alizé Cornet → replaced by 
Francesca Di Lorenzo
Katarzyna Kawa → replaced by Alexandra Dulgheru Liudmila Samsonova → replaced by Clara Burel Sloane Stephens → replaced by 
Mandy Minella Martina Trevisan → replaced by Marina Melnikova| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Russian Federation | ||||||
| Jil Teichmann | Tamara Zidanšek | 170 | 2 | |||
 Japan | Eri Hozumi |  China | Zhang Shuai | 180 | 3 | |
| Poland | Katarzyna Piter | Arantxa Rus | 200 | 4 |
The following pairs received wildcards into the doubles main draw:
The following pair received entry as alternates:
Akgul Amanmuradova / Valentina Ivakhnenko → replaced by Valentina Ivakhnenko / 
Jesika Malečková Anna Blinkova / Anna-Lena Friedsam → replaced by Elena Bogdan / Alexandra Dulgheru
Oksana Kalashnikova → replaced by Mandy Minella / Stefanie Vögele