See main article: article and 2021 LTP Charleston Pro Tennis II.
Anna Danilina and Ingrid Neel were the defending champions, having won the previous edition in 2019,[1] but both players chose not to participate.
Fanny Stollár and Aldila Sutjiadi won the title, defeating Rasheeda McAdoo and Peyton Stearns in the final, 6–0, 6–4.