| Date: | 21–27 June 2021 |
| Edition: | 6th |
| Surface: | Clay |
| Location: | Charleston, South Carolina, United States |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: | Despina Papamichail |
| Champd: |  Fanny Stollár / Aldila Sutjiadi |
| Before Year: | 2019 |
| Main Name: | LTP Charleston Pro Tennis |
| After Name: | LTP Charleston Pro Tennis 2 |
The 2021 LTP Charleston Pro Tennis II was a professional women's tennis tournament played on outdoor clay courts. It was the sixth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Charleston, South Carolina, United States between 21 and 27 June 2021.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Conny Perrin | 251 | 1 | ||
| Despina Papamichail | 258 | 2 | ||
| Hanna Chang | 268 | 3 | ||
| Alycia Parks | 275 | 4 | ||
 Japan | Kyōka Okamura | 280 | 5 | |
 Brazil | Gabriela Cé | 281 | 6 | |
 Mexico | Marcela Zacarías | 300 | 7 | |
| Alexa Glatch | 303 | 8 |
The following players received wildcards into the singles main draw:
Elvina Kalieva Emma Navarro Taylor Ng Eleana YuThe following player received entry using a protected ranking:
The following player received entry as a special exempt:
The following players received entry from the qualifying draw:
Charlotte Chavatipon Louisa Chirico Emma Davis Quinn Gleason
Paige Hourigan Maria Sanchez Erika SemaSee main article: 2021 LTP Charleston Pro Tennis II – Singles.
Gabriela Cé, 1–6, 6–3, 6–3See main article: 2021 LTP Charleston Pro Tennis II – Doubles.
Fanny Stollár / Aldila Sutjiadi def. Rasheeda McAdoo / Peyton Stearns, 6–0, 6–4