| Date: | 3–9 May 2021 |
| Edition: | 5th |
| Surface: | Clay |
| Location: | Charleston, South Carolina, United States |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $100,000 |
| Champs: |  Claire Liu |
| Champd: | Caty McNally /  Storm Sanders |
The 2021 LTP Charleston Pro Tennis was a professional women's tennis tournament played on outdoor clay courts. It was the fifth edition of the tournament which is part of the 2021 ITF Women's World Tennis Tour. It took place in Charleston, South Carolina, United States between 3 and 9 May 2021.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Madison Brengle | 86 | 1 | ||
| Caty McNally | 110 | 2 | ||
 Egypt | Mayar Sherif | 123 | 3 | |
| Kristie Ahn | 124 | 4 | ||
 Romania | Irina Bara | 133 | 5 | |
 Mexico | Renata Zarazúa | 141 | 6 | |
 Belarus | Olga Govortsova | 142 | 7 | |
 China | Wang Xinyu | 145 | 8 |
The following players received wildcards into the singles main draw:
Caty McNally Alycia Parks Kennedy Shaffer Katie VolynetsThe following player received entry as a special exempt:
The following players received entry from the qualifying draw:
Amina Anshba Victoria Duval
Eri Hozumi
Aleksandra Krunić Jamie Loeb
Urszula RadwańskaSee main article: 2021 LTP Charleston Pro Tennis – Singles.
Claire Liu def. Madison Brengle, 6–2, 7–6(8–6)See main article: 2021 LTP Charleston Pro Tennis – Doubles.
Caty McNally / Storm Sanders def. Eri Hozumi / Miyu Kato 7–5, 4–6, [10–6]