| Date: | 30 August–5 September 2021 |
| Edition: | 8th |
| Surface: | Clay |
| Location: | Prague, Czech Republic |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Magdalena Fręch |
| Champd: |  Miriam Kolodziejová / Jesika Malečková |
The 2021 Kuchyně Gorenje Prague Open was a professional women's tennis tournament played on outdoor clay courts. It was the eighth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Prague, Czech Republic between 30 August and 5 September 2021.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Poland | Magdalena Fręch | 123 | 1 | |
| Poland | Katarzyna Kawa | 164 | 2 | |
 Hungary | Panna Udvardy | 168 | 3 | |
| Leonie Küng | 169 | 4 | ||
 Italy | Lucia Bronzetti | 172 | 5 | |
 Slovakia | Rebecca Šramková | 187 | 6 | |
| Italy | Lucrezia Stefanini | 213 | 7 | |
 France | Diane Parry | 223 | 8 |
The following players received wildcards into the singles main draw:
Sára Bejlek Monika Kilnarová Linda Nosková Darja ViďmanováThe following players received entry from the qualifying draw:
Alexandra Bozovic
Lina Glushko
Mana Kawamura Alice Ramé Tereza Smitková
Valeriya StrakhovaSee main article: 2021 Kuchyně Gorenje Prague Open – Singles.
Magdalena Fręch def. Tereza Smitková, 6–2, 6–1See main article: 2021 Kuchyně Gorenje Prague Open – Doubles.
Miriam Kolodziejová / Jesika Malečková def. Kanako Morisaki / Erika Sema, 6–3, 1–6, [10–2]