See main article: article and 2021 Karlsruhe Open.
Lara Arruabarrena and Renata Voráčová were the defending champions having won the previous edition in 2019,[1] but chose not to participate.
Irina Bara and Ekaterine Gorgodze won the title, defeating Katarzyna Piter and Mayar Sherif in the final, 6–3, 2–6, [10–7].