See main article: 2021 Internazionali di Tennis del Friuli Venezia Giulia.
Ariel Behar and Andrey Golubev were the defending champions[1] but chose not to defend their title.
Orlando Luz and Rafael Matos won the title after defeating Sergio Galdós and Renzo Olivo 6–4, 7–6(7–5) in the final.