| Date: | 2–8 August |
| Edition: | 18th |
| Category: | ATP Challenger Tour |
| Surface: | Clay / outdoor |
| Location: | Cordenons, Italy |
| Champs: |  Francisco Cerúndolo |
| Champd: |  Orlando Luz / Rafael Matos |
The 2021 Internazionali di Tennis del Friuli Venezia Giulia was a professional tennis tournament played on clay courts. It was the 18th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Cordenons, Italy between 2 and 8 August 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Italy | Stefano Travaglia | 88 | 1 | |
 France | Gilles Simon | 102 | 2 | |
| Argentina | Francisco Cerúndolo | 118 | 3 | |
 Peru | Juan Pablo Varillas | 125 | 4 | |
 Bolivia, Plurination;al State of | Hugo Dellien | 140 | 5 | |
| France | Antoine Hoang | 145 | 6 | |
| Argentina | Juan Manuel Cerúndolo | 146 | 7 | |
| Italy | Federico Gaio | 149 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as a special exempt:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
See main article: 2021 Internazionali di Tennis del Friuli Venezia Giulia – Singles.
Francisco Cerúndolo def. Tomás Martín Etcheverry 6–1, 6–2.See main article: 2021 Internazionali di Tennis del Friuli Venezia Giulia – Doubles.
Orlando Luz / Rafael Matos def. Sergio Galdós / Renzo Olivo 6–4, 7–6(7–5).
