See main article: 2021 Internazionali di Tennis Città di Trieste.
Ariel Behar and Andrey Golubev were the defending champions[1] but chose not to defend their title.
Orlando Luz and Felipe Meligeni Alves won the title after defeating Antoine Hoang and Albano Olivetti 7–5, 6–7(6–8), [10–5] in the final.