| Date: | 12–18 July |
| Edition: | 15th |
| Surface: | Clay |
| Location: | Todi, Italy |
| Champs: |  Mario Vilella Martínez |
| Champd: |  Francesco Forti / Giulio Zeppieri |
The 2021 Internazionali di Tennis Città di Todi was a professional tennis tournament played on clay courts. It was the 15th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Todi, Italy between 12 and 18 July 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Italy | Federico Gaio | 145 | 1 | |
| Spain | Mario Vilella Martínez | 179 | 2 | |
 Kazakhstan | Dmitry Popko | 187 | 3 | |
 Argentina | Tomás Martín Etcheverry | 192 | 4 | |
| Argentina | Renzo Olivo | 193 | 5 | |
| Argentina | Andrea Collarini | 206 | 6 | |
| Italy | Gian Marco Moroni | 218 | 7 | |
| Italy | Lorenzo Giustino | 228 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2021 Internazionali di Tennis Città di Todi – Singles.
Mario Vilella Martínez def. Federico Gaio 7–6(7–3), 1–6, 6–3.See main article: 2021 Internazionali di Tennis Città di Todi – Doubles.
Francesco Forti / Giulio Zeppieri def. Facundo Díaz Acosta / 
Alexander Merino 6–3, 6–2.
