See main article: article and 2021 Internazionali Femminili di Palermo.
Fiona Ferro was the defending champion,[1] but she chose not to participate, as she was competing at the Summer Olympics.
Top seed Danielle Collins won her maiden WTA Tour singles title, defeating Elena-Gabriela Ruse in the final, 6–4, 6–2. Collins did not drop a set during the tournament.