See main article: article and 2021 Internazionali Femminili di Palermo.
Arantxa Rus and Tamara Zidanšek were the reigning champions,[1] but chose not to participate.
Erin Routliffe and Kimberley Zimmermann won the title, defeating Natela Dzalamidze and Kamilla Rakhimova in the final, 7–6(7–5), 4–6, [10–4].