See main article: 2021 Internationaux de Tennis de Vendée.
Jonny O'Mara and Ken Skupski were the defending champions[1] but only O'Mara chose to defend his title, partnering Treat Huey. O'Mara lost in the first round to Antoine Hoang and Kyrian Jacquet.
Jonathan Eysseric and Quentin Halys won the title after defeating David Pel and Aisam-ul-Haq Qureshi 4–6, 7–6(7–5), [10–8] in the final.