| Date: | 4–10 October |
| Edition: | 8th |
| Surface: | Hard (Indoor) |
| Location: | Mouilleron-le-Captif, France |
| Champs: |  Jiří Veselý |
| Champd: |  Jonathan Eysseric / Quentin Halys |
| Before Year: | 2019 |
The 2021 Internationaux de Tennis de Vendée was a professional tennis tournament played on hard courts. It was the eighth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Mouilleron-le-Captif, France between 4 and 10 October 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| France | Benjamin Bonzi | 64 | 1 | |
| Czech Republic | Jiří Veselý | 86 | 2 | |
| Peter Gojowczyk | 87 | 3 | ||
 Italy | Andreas Seppi | 95 | 4 | |
| France | ||||
| France | Pierre-Hugues Herbert | 100 | 6 | |
 Lithuania | Ričardas Berankis | 106 | 7 | |
 Slovakia | Norbert Gombos | 114 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2021 Internationaux de Tennis de Vendée – Singles.
Jiří Veselý def. Norbert Gombos 6–4, 6–4.See main article: 2021 Internationaux de Tennis de Vendée – Doubles.
Jonathan Eysseric / Quentin Halys def. David Pel / 
Aisam-ul-Haq Qureshi 4–6, 7–6(7–5), [10–8].
