| Date: | 19–25 July 2021 |
| Edition: | 12th |
| Surface: | Clay |
| Location: | Olomouc, Czech Republic |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Sára Bejlek |
| Champd: |  Jessie Aney / Anna Sisková |
| Before Year: | 2019 |
The 2021 ITS Cup was a professional women's tennis tournament played on outdoor clay courts. It was the twelfth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Olomouc, Czech Republic between 19 and 25 July 2021.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Hungary | Panna Udvardy | 204 | 1 | |
 United Kingdom | Francesca Jones | 206 | 2 | |
 France | Amandine Hesse | 211 | 3 | |
| Susan Bandecchi | 219 | 4 | ||
| Simona Waltert | 235 | 5 | ||
 Italy | Jessica Pieri | 244 | 6 | |
| Richèl Hogenkamp | 246 | 7 | ||
 Mexico | Ana Sofía Sánchez | 251 | 8 |
The following players received wildcards into the singles main draw:
Nikola Bartůňková Sára Bejlek Nikola Břečková Anna SiskováThe following player received entry using a protected ranking:
The following player received entry using a junior exempt:
The following players received entry from the qualifying draw:
Miriam Bulgaru Elizabeth Halbauer Monika Kilnarová Julie ŠtruplováSee main article: 2021 ITS Cup – Singles.
Sára Bejlek def. 
Paula Ormaechea, 6–0, 6–0See main article: 2021 ITS Cup – Doubles.
Jessie Aney / Anna Sisková def. Bárbara Gatica / 
Rebeca Pereira, 6–1, 6–0