| Date: | 5–11 April 2021 |
| Edition: | 1st |
| Surface: | Clay |
| Location: | Bellinzona, Switzerland |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Julia Grabher |
| Champd: |  Anna Danilina /  Ekaterine Gorgodze |
| After Name: | Bellinzona Ladies Open |
The 2021 ITF Women's World Tennis Tour – Bellinzona was a professional women's tennis tournament played on outdoor clay courts. It was the first edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Bellinzona, Switzerland between 5 and 11 April 2021.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 France | Océane Dodin | 120 | 1 | |
 Ukraine | Katarina Zavatska | 128 | 2 | |
 China | Wang Xiyu | 135 | 3 | |
 Romania | Elena-Gabriela Ruse | 163 | 4 | |
| Ukraine | Anhelina Kalinina | 167 | 5 | |
 Turkey | Çağla Büyükakçay | 179 | 6 | |
| Antonia Lottner | 186 | 7 | ||
| Mona Barthel | 188 | 8 | ||
 Japan | Yuki Naito | 189 | 9 | |
| China | Lu Jiajing | 196 | 10 | |
 Italy | Martina Di Giuseppe | 200 | 11 | |
| Romania | Laura Ioana Paar | 201 | 12 | |
| Jana Fett | 210 | 13 | ||
 Korea, Republic of | Han Na-lae | 212 | 14 | |
| Isabella Shinikova | 218 | 15 | ||
 Canada | Rebecca Marino | 222 | 16 |
The following players received wildcards into the singles main draw:[2]
The following player received entry using a junior exempt:
The following players received entry from the qualifying draw:
Lucia Bronzetti
Lina Gjorcheska
Seone Mendez Camilla Rosatello
Raluca Șerban Lucrezia StefaniniThe following player received entry as a lucky loser:
See main article: 2021 ITF Women's World Tennis Tour – Bellinzona – Singles.
Julia Grabher def. Lucia Bronzetti, 6–2, 6–3See main article: 2021 ITF Women's World Tennis Tour – Bellinzona – Doubles.
Anna Danilina / Ekaterine Gorgodze def. Rebecca Marino / Yuki Naito, 7–5, 6–3