| Date: | 4–10 October 2021 |
| Edition: | 12th |
| Surface: | Hard |
| Location: | Henderson, Las Vegas, United States |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Emina Bektas |
| Champd: | Quinn Gleason /  Tereza Mihalíková |
| Before Year: | 2019 |
The 2021 Henderson Tennis Open was a professional women's tennis tournament played on outdoor hard courts. It was the twelfth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Henderson, Las Vegas, United States between 4 and 10 October 2021.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Conny Perrin | 225 | 1 | ||
| Allie Kiick | 250 | 2 | ||
 Japan | Yuriko Lily Miyazaki | 252 | 3 | |
| Hanna Chang | 262 | 4 | ||
| Alexa Glatch | 271 | 5 | ||
| Emina Bektas | 331 | 6 | ||
| Lulu Sun | 352 | 7 | ||
| Japan | Nagi Hanatani | 376 | 8 |
The following players received wildcards into the singles main draw:
Haley Giavara Rasheeda McAdoo Shatoo Mohamad Alexandra RileyThe following players received entry using protected rankings:
The following players received entry from the qualifying draw:
Shir Azran Ibifuro Clement
Molly Helgesson Tricia Mar Rhiann Newborn Erica Oosterhout Holly Verner
Marcela ZacaríasSee main article: 2021 Henderson Tennis Open – Singles.
Emina Bektas def. Yuriko Lily Miyazaki, 6–1, 6–1See main article: 2021 Henderson Tennis Open – Doubles.
Quinn Gleason / Tereza Mihalíková def. Emina Bektas / 
Tara Moore, 7–6(7–5), 7–5