| 2021 Grote Prijs Jef Scherens | |
| Series: | 2021 UCI Europe Tour |
| Date: | 15 August 2021 |
| Stages: | 1 |
| Distance: | 190 |
| Unit: | km |
| First: | Niccolò Bonifazio |
| First Nat: | ITA |
| Second: | Nacer Bouhanni |
| Second Nat: | FRA |
| Third: | Gianni Vermeersch |
| Third Nat: | BEL |
| Previous: | 2019 |
| Next: | 2022 |
The 2021 Grote Prijs Jef Scherens was the 54th edition of the Grote Prijs Jef Scherens road cycling one day race in and around Leuven.[1] It was held on 15 August 2021 as a 1.1 categorised race and was part of the 2021 UCI Europe Tour and the 2021 Belgian Road Cycling Cup. The race course overlaps to a large part with that of the 2021 UCI Road World Championships, which are to be held a few weeks later.
The defending champion is sprinter Niccolò Bonifazio, who won the 2019 edition as no race was held in 2020 due to the COVID-19 pandemic in Belgium. Besides Bonifazio, other sprinters present included Tim Merlier, Baptiste Planckaert, Nacer Bouhanni and Bryan Coquard . It was won by the defending champion Bonifazio in the sprint.
Twenty-two teams were invited to take part in the race. These included one UCI World Tour team, six UCI Professional Continental teams, and fifteen UCI Continental teams.