| Champ: |  Jannik Sinner |
| Runner: | Stefano Travaglia |
| Score: | 7–6(7–4), 6–4 |
| Type: | singles doubles |
| Main Name: | Australian Open Series |
| Before Name: | Adelaide International |
See main article: 2021 Great Ocean Road Open.
The Great Ocean Road Open was a new addition to the ATP Tour in 2021.
Jannik Sinner won the title, defeating Stefano Travaglia in the final, 7–6(7–4), 6–4. He saved a match point against Karen Khachanov in the semifinal.
The top eight seeds received a bye into the second round.
See also: 1 and 1. 
David Goffin (second round)
See also: 2 and 4. 
Karen Khachanov (semifinals)
See also: 3 and 2. 
Hubert Hurkacz (quarterfinals)
See also: 4 and 3. Jannik Sinner (champion)
See also: 5 and 1. 
Nikoloz Basilashvili (second round)
See also: 6 and 4. 
Reilly Opelka (third round)
See also: 7 and 3. 
Miomir Kecmanović (quarterfinals)
See also: 8 and 2. 
Alexander Bublik (third round)
See also: 9 and 3. Tennys Sandgren (second round)
See also: 10 and 2. Sam Querrey (second round)
See also: 11 and 1. 
Jordan Thompson (quarterfinals)
See also: 12 and 4. Laslo Đere (first round)
See also: 13 and 3. Aljaž Bedene (third round)
See also: 14 and 2. 
Pablo Andújar (first round)
See also: 15. 
Vasek Pospisil (withdrew)
See also: 16 and 4. Feliciano López (first round)