| Date: | 5–11 July 2021 |
| Edition: | 14th |
| Surface: | Clay |
| Location: | Contrexéville, France |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $100,000 |
| Champs: |  Anhelina Kalinina |
| Champd: |  Anna Danilina /  Ulrikke Eikeri |
| Before Year: | 2019 |
The 2021 Grand Est Open 88 was a professional women's tennis tournament played on outdoor clay courts. It was the fourteenth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Contrexéville, France between 5 and 11 July 2021.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Italy | Martina Trevisan | 98 | 1 | |
 France | Océane Dodin | 113 | 2 | |
| Stefanie Vögele | 121 | 3 | ||
| Ukraine | Anhelina Kalinina | 125 | 4 | |
 Hungary | Réka Luca Jani | 181 | 5 | |
 China | Zheng Qinwen | 194 | 6 | |
| Jana Fett | 200 | 7 | ||
| Hungary | Dalma Gálfi | 205 | 8 |
The following players received wildcards into the singles main draw:
Loïs Boisson Elsa Jacquemot Marine Partaud Lucie WargnierThe following player received entry using a protected ranking:
The following players received entry from the qualifying draw:
Émeline Dartron
Weronika Falkowska Léolia Jeanjean Margaux Rouvroy
Oksana Selekhmeteva Valeriya StrakhovaSee main article: 2021 Grand Est Open 88 – Singles.
Anhelina Kalinina def. Dalma Gálfi, 6–2, 6–2See main article: 2021 Grand Est Open 88 – Doubles.
Anna Danilina / Ulrikke Eikeri def. Dalma Gálfi / 
Kimberley Zimmermann, 6–0, 1–6, [10–4]