| Date: | 1–7 March |
| Edition: | 2nd |
| Surface: | Clay |
| Location: | Las Palmas, Spain |
| Champs: |  Carlos Gimeno Valero |
| Champd: |  Enzo Couacaud / Manuel Guinard |
| Before Name: | Gran Canaria Challenger |
| Before Year: | 2021 |
| Main Name: | Gran Canaria Challenger |
| After Name: | Gran Canaria Challenger |
The 2021 Gran Canaria Challenger II was a professional tennis tournament played on clay courts. It was the second edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Las Palmas, Spain between 1 and 7 March 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Spain | Carlos Alcaraz | 127 | 1 | |
 Italy | Federico Gaio | 133 | 2 | |
 Serbia | Nikola Milojević | 149 | 3 | |
| Serbia | Danilo Petrović | 154 | 4 | |
| Italy | Lorenzo Giustino | 158 | 5 | |
| Italy | Alessandro Giannessi | 163 | 6 | |
 Slovakia | Filip Horanský | 170 | 7 | |
 Belgium | Kimmer Coppejans | 182 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Eduard Esteve Lobato
Filip Cristian Jianu
Emilio Nava Giulio ZeppieriThe following player received entry as a lucky loser:
See main article: 2021 Gran Canaria Challenger II – Singles.
Carlos Gimeno Valero def. Kimmer Coppejans 6–4, 6–2.See main article: 2021 Gran Canaria Challenger II – Doubles.
Enzo Couacaud / Manuel Guinard def. Javier Barranco Cosano / Eduard Esteve Lobato 6–1, 6–4.