| Date: | 22–28 February |
| Edition: | 1st |
| Surface: | Clay |
| Location: | Las Palmas, Spain |
| Champs: |  Enzo Couacaud |
| Champd: |  Lloyd Glasspool /  Harri Heliövaara |
| After Name: | Gran Canaria Challenger II |
| After Year: | 2021 |
The 2021 Gran Canaria Challenger was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Las Palmas, Spain between 22 and 28 February 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Italy | Lorenzo Musetti | 122 | 1 | |
 Spain | Carlos Taberner | 128 | 2 | |
| Italy | Federico Gaio | 140 | 3 | |
 Serbia | Nikola Milojević | 145 | 4 | |
| Serbia | Danilo Petrović | 153 | 5 | |
| Italy | Lorenzo Giustino | 157 | 6 | |
| Italy | Alessandro Giannessi | 160 | 7 | |
 Slovakia | Filip Horanský | 164 | 8 |
The following players received wildcards into the singles main draw:
Javier Barranco Cosano Carlos Gimeno ValeroThe following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Manuel Guinard Àlex Martí Pujolràs Alex Molčan
Emilio NavaSee main article: 2021 Gran Canaria Challenger – Singles.
Enzo Couacaud def. 
Steven Diez 7–6(7–5), 7–6(7–3).See main article: 2021 Gran Canaria Challenger – Doubles.
Lloyd Glasspool / Harri Heliövaara def. 
Kimmer Coppejans / Sergio Martos Gornés 7–5, 6–1.