| Date: | 25–31 January 2021 |
| Edition: | 1st |
| Surface: | Hard |
| Location: | Rome, Georgia, United States |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Irene Burillo Escorihuela |
| Champd: |  Emina Bektas /  Tara Moore |
The 2021 Georgia's Rome Tennis Open was a professional women's tennis tournament played on outdoor hard courts. It was the first edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Rome, Georgia, United States between 25 and 31 January 2021.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Belarus | Olga Govortsova | 134 | 1 | |
 Mexico | Renata Zarazúa | 142 | 2 | |
| Francesca Di Lorenzo | 143 | 3 | ||
 Slovakia | Kristína Kučová | 147 | 4 | |
| Usue Maitane Arconada | 155 | 5 | ||
| Verónica Cepede Royg | 175 | 7 | ||
 Colombia | Camila Osorio | 186 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry using a protected ranking:
The following players received entry from the qualifying draw:
Emina Bektas Irene Burillo Escorihuela Sarah Hamner Kimmi Hance Robin Montgomery Tara Moore Ana Sofía Sánchez
Panna UdvardyThe following player received entry as a lucky loser:
See main article: 2021 Georgia's Rome Tennis Open – Singles.
Irene Burillo Escorihuela def. Grace Min, 1–6, 7–6(7–4), 6–1See main article: 2021 Georgia's Rome Tennis Open – Doubles.
Emina Bektas / Tara Moore def. Olga Govortsova / 
Jovana Jović, 5–7, 6–2, [10–8]