| Year: | 2021 |
| Team: | Gardner–Webb Runnin' Bulldogs |
| Sport: | football |
| Conference: | Big South Conference |
| Short Conf: | Big South |
| Record: | 4–7 |
| Conf Record: | 2–5 |
| Head Coach: | Tre Lamb |
| Hc Year: | 2nd |
| Off Coach: | Taylor Lamb |
| Oc Year: | 1st |
| Def Coach: | Josh Reardon |
| Dc Year: | 2nd |
| Stadium: | Ernest W. Spangler Stadium |
The 2021 Gardner–Webb Runnin' Bulldogs football team represented Gardner–Webb University as a member of the Big South Conference during the 2021 NCAA Division I FCS football season. Led by second-year head coach Tre Lamb, the Runnin' Bulldogs compiled an overall record of 4–7 with a mark of 2–5 in conference play, placing in a three-way tie for seventh in the Big South. Gardner–Webb played home games at Ernest W. Spangler Stadium in Boiling Springs, North Carolina.