See main article: article and 2021 French Open.
Barbora Krejčíková and Kateřina Siniaková defeated Bethanie Mattek-Sands and Iga Świątek in the final, 6–4, 6–2 to win the women's doubles tennis title at the 2021 French Open. It was their second French Open title and third major title together. Krejčíková became the first woman to win both the singles and doubles tournaments at a major since Serena Williams at the 2016 Wimbledon Championships, and the first to do so at the French Open since Mary Pierce in 2000, making her the seventh woman to accomplish the sweep in French Open history.[1] Mattek-Sands and Świątek reached the final after saving seven match points in their third round match against Hsieh Su-wei and Elise Mertens.
By winning the title, Krejčíková also reclaimed the world No. 1 doubles ranking. Kristina Mladenovic and Hsieh Su-wei were both in contention for the ranking, but Mladenovic did not participate and Hsieh lost in the third round.
Tímea Babos and Mladenovic were the two-time reigning champions,[2] but Mladenovic did not participate. Babos partnered Vera Zvonareva, but the pair were defeated in the first round by Petra Martić and Shelby Rogers.
Paula Badosa / 
Alizé Cornet → replaced by Paula Badosa / Aliona Bolsova
Ashleigh Barty / 
Jennifer Brady → replaced by 
Greet Minnen / Alison Van Uytvanck Sofia Kenin → replaced by 
Zarina Diyas / 
Varvara Gracheva Hayley Carter / 
Luisa Stefani → replaced by Hayley Carter / Astra Sharma Coco Gauff / Caty McNally → replaced by Coco Gauff / Venus Williams
Nina Stojanović / Jil Teichmann → replaced by 
Jasmine Paolini / Nina Stojanović
