| Champ: | Diede de Groot Aniek van Koot |
| Runner: |  Yui Kamiji Jordanne Whiley |
| Score: | 6–3, 6–4 |
See main article: 2021 French Open.
Three-time defending champions Diede de Groot and Aniek van Koot[1] defeated Yui Kamiji and Jordanne Whiley in the final, 6–3, 6–4 to win the women's doubles wheelchair tennis title at the 2021 French Open.