| Champ: | Diede de Groot |
| Runner: |  Yui Kamiji |
| Score: | 6–4, 6–3 |
See main article: 2021 French Open.
Diede de Groot defeated the defending champion Yui Kamiji[1] in the final, 6–4, 6–3 to win the women's singles wheelchair tennis title at the 2021 French Open. It was the second step in an eventual Super Slam for de Groot, and she completed the double career Grand Slam with the win.