| 2021 Europe Top 16 Cup | |
| Dates: | 18–19 September 2021 |
| Number Edition: | 50th |
| Competitors: | 32 |
| Venue: | YMCA Sports Center |
| Location: | Thessaloniki, Greece |
| Ms: | Patrick Franziska |
| Country Ms: | GER |
| Ws: | Nina Mittelham |
| Country Ws: | GER |
| Previous: | 2020 |
| Next: | 2022 |
The 2021 Europe Top 16 Cup (also referred to as the 2021 Pomegranate Europe Top 16 Cup for sponsorship reasons) was a table tennis competition, held on 18 and 19 September 2021 in Thessaloniki, Greece, organised under the authority of the European Table Tennis Union (ETTU). It was the 50th edition of the event, and the first time that it had been held in Greece.[1] [2]
| Men's Singles | Patrick Franziska | Marcos Freitas |  Mattias Falck Emmanuel Lebesson |
| Women's Singles | Nina Mittelham | Fu Yu |  Hana Matelová Bernadette Szőcs |
Players were seeded according to the latest European ranking.[3]
Players were seeded according to the latest European ranking.[3]