| Date: | 10–16 May 2021 |
| Edition: | 24th |
| Surface: | Clay |
| Location: | Saint-Gaudens, France |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Clara Burel |
| Champd: | Estelle Cascino / Jessika Ponchet |
| Before Year: | 2019 |
| Main Name: | Open Saint-Gaudens Occitanie |
| After Name: | Edge Open Saint-Gaudens Occitanie |
The 2021 Engie Open Saint-Gaudens Occitanie was a professional women's tennis tournament played on outdoor clay courts. It was the twenty-fourth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Saint-Gaudens, France between 10 and 16 May 2021.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Viktorija Golubic | 84 | 1 | ||
| France | Océane Dodin | 117 | 2 | |
 Slovakia | Kristína Kučová | 151 | 3 | |
 Japan | Kurumi Nara | 153 | 4 | |
 Austria | Barbara Haas | 156 | 5 | |
| France | ||||
| France | Clara Burel | 164 | 7 | |
 Spain | Cristina Bucșa | 167 | 8 | |
 Romania | Elena-Gabriela Ruse | 175 | 9 |
The following players received wildcards into the singles main draw:
Océane Babel Aubane Droguet María Gutiérrez Carrasco Séléna JanicijevicThe following player received entry using a protected ranking:
The following player received entry as a junior exempt:
The following players received entry from the qualifying draw:
Tessah Andrianjafitrimo Loïs Boisson
Anna Bondár Diane Parry Alice Ramé Margot YerolymosThe following player received entry as a lucky loser:
See main article: 2021 Engie Open Saint-Gaudens Occitanie – Singles.
Clara Burel def. Alexandra Dulgheru, 6–2, 1–6, 6–2See main article: 2021 Engie Open Saint-Gaudens Occitanie – Doubles.
Estelle Cascino / Jessika Ponchet def. 
Eden Silva / 
Kimberley Zimmermann, 0–6, 7–5, [10–7]