| Date: | 1–7 November 2021 |
| Edition: | 17th |
| Surface: | Hard / Indoor |
| Location: | Nantes, France |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Anhelina Kalinina |
| Champd: |  Samantha Murray Sharan /  Jessika Ponchet |
| Before Year: | 2019 |
| Main Name: | Open Nantes Atlantique |
The 2021 Engie Open Nantes Atlantique was a professional women's tennis tournament played on indoor hard courts. It was the seventeenth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Nantes, France between 1 and 7 November 2021.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Ukraine | Anhelina Kalinina | 59 | 1 | |
 Russian Federation | Varvara Gracheva | 81 | 2 | |
| France | Océane Dodin | 93 | 3 | |
 Italy | Martina Trevisan | 113 | 4 | |
| Russian Federation | Kamilla Rakhimova | 118 | 5 | |
| Polona Hercog | 124 | 6 | ||
| Russian Federation | Vitalia Diatchenko | 135 | 7 | |
 China | Zheng Qinwen | 151 | 8 |
The following players received wildcards into the singles main draw:
Audrey Albié Carole Monnet Mallaurie Noël Alice RobbeThe following player received entry using a protected ranking:
The following player received entry as a special exempt:
The following players received entry from the qualifying draw:
Erika Andreeva
Emina Bektas Sara Cakarevic Sarah Beth Grey
Sada Nahimana
İpek Soylu
Raluca ȘerbanThe following players received entry as lucky losers:
See main article: 2021 Engie Open Nantes Atlantique – Singles.
Anhelina Kalinina def. Océane Dodin, 7–6(7–4), 1–0, ret.See main article: 2021 Engie Open Nantes Atlantique – Doubles.
Samantha Murray Sharan / Jessika Ponchet def. Alicia Barnett / Olivia Nicholls, 6–4, 6–2