| Date: | 25–31 January 2021 |
| Edition: | 11th |
| Surface: | Hard / Indoor |
| Location: | Andrézieux-Bouthéon, France |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Harmony Tan |
| Champd: |  Lu Jiajing / You Xiaodi |
| Main Name: | Open Andrézieux-Bouthéon 42 |
The 2021 Engie Open Andrézieux-Bouthéon 42 was a professional women's tennis tournament played on indoor hard courts. It was the eleventh edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Andrézieux-Bouthéon, France between 25 and 31 January 2021.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| France | Océane Dodin | 107 | 1 | |
| Anna-Lena Friedsam | 111 | 2 | ||
| Stefanie Vögele | 116 | 3 | ||
 Ukraine | Katarina Zavatska | 119 | 4 | |
 Czech Republic | Tereza Martincová | 121 | 5 | |
| Tamara Korpatsch | 126 | 6 | ||
| Viktoriya Tomova | 139 | 7 | ||
| Clara Tauson | 152 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry using a junior exempt:
The following player received entry using a protected ranking:
The following players received entry from the qualifying draw:
Gaëlle Desperrier
Federica Di Sarra Salma Djoubri
Rebecca Šramková
Urszula Radwańska
Kathinka von DeichmannSee main article: 2021 Engie Open Andrézieux-Bouthéon 42 – Singles.
Harmony Tan def. 
Jaqueline Cristian, 3–6, 6–2, 6–1See main article: 2021 Engie Open Andrézieux-Bouthéon 42 – Doubles.
Lu Jiajing / You Xiaodi def. Paula Kania-Choduń / Katarina Zavatska, 6–3, 6–4