| Year: | 2021 |
| Team: | Duquesne Dukes |
| Sport: | football |
| Conference: | Northeast Conference |
| Short Conf: | NEC |
| Record: | 7–3 |
| Conf Record: | 5–2 |
| Head Coach: | Jerry Schmitt |
| Hc Year: | 17th |
| Off Coach: | Anthony Doria |
| Oc Year: | 6th |
| Def Coach: | Dave Opfar |
| Dc Year: | 12th |
The 2021 Duquesne Dukes football team represented Duquesne University as a member of the Northeast Conference (NEC) in the 2021 NCAA Division I FCS football season. The Dukes, led by 17th-year head coach Jerry Schmitt, played their home games at Arthur J. Rooney Athletic Field.
See also: 2021 TCU Horned Frogs football team.
| Statistics | DUQ | TCU |
|---|---|---|
| First downs | 6 | 26 |
| Total yards | 137 | 431 |
| Rushes/yards | 29/61 | 38/178 |
| Passing yards | 76 | 253 |
| Passing: Comp–Att–Int | 3–12–1 | 18–24–1 |
| Time of possession | 29:19 | 30:41 |
| Team | Category | Player | Statistics |
|---|---|---|---|
| Duquesne | Passing | Darius Perrantes | 3–9, 76 yards |
| Rushing | Garrett Owens | 14 carries, 35 yards | |
| Receiving | Cyrus Holder | 2 receptions, 64 yards | |
| TCU | Passing | Max Duggan | 14–19, 207 yards, 1 TD, 1 INT |
| Rushing | Kendre Miller | 8 carries, 54 yards, 1 TD | |
| Receiving | Derius Davis | 2 receptions, 57 yards |