The 2021 Courmayeur Ladies Open was a women's tennis tournament played on indoor hard courts.[1] It was the first edition of the Courmayeur Ladies Open, and part of the WTA 250 series of the 2021 WTA Tour. It was held at the Courmayeur Sport Center in Courmayeur, Italy, from 25 until 31 October, 2021.[2]
See main article: 2021 Courmayeur Ladies Open – Singles.
This was Vekić's third WTA singles title, and first since 2017.
See main article: 2021 Courmayeur Ladies Open – Doubles.
Wang Xinyu / Zheng Saisai def. 
Eri Hozumi / Zhang Shuai 6–4, 3–6, [10–5]| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Tunisia | ||||
 Italy | ||||
 Russian Federation | Liudmila Samsonova | 42 | 3 | |
| Petra Martić | 47 | 4 | ||
| Clara Tauson | 48 | 5 | ||
 United States | Alison Riske | 49 | 6 | |
| Italy | Jasmine Paolini | 54 | 7 | |
| China | Zhang Shuai | 55 | 8 | |
| United States | Ann Li | 60 | 9 | |
 Ukraine | Dayana Yastremska | 76 | 10 |
The following players received wildcards into the main draw:
The following players received entry using a protected ranking into the main draw:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Kamilla Rakhimova Danielle Collins → replaced by Anna Kalinskaya Camila Giorgi → replaced by 
Urszula Radwańska Ons Jabeur → replaced by 
Ankita Raina
Tereza Martincová → replaced by 
Mandy Minella
Greet Minnen → replaced by Hsieh Su-wei
Nuria Párrizas Díaz → replaced by Donna Vekić
Elena Rybakina → replaced by Kateryna Kozlova Kateřina Siniaková → replaced by Lucia Bronzetti Sara Sorribes Tormo → replaced by Magdalena Fręch| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Czech Republic | Marie Bouzková | Czech Republic | Lucie Hradecká | 67 | 1 | |
| Ukraine | Nadiia Kichenok |  Romania | Raluca Olaru | 73 | 1 | |
| Japan | Eri Hozumi | China | Zhang Shuai | 83 | 3 | |
 France | Elixane Lechemia | United States | Sabrina Santamaria | 141 | 4 |
The following pairs received wildcards into the doubles main draw:
The following pair received entry as alternates:
Cristiana Ferrando / Hsieh Su-wei → replaced by Natalia Vikhlyantseva / Zheng Qinwen Vitalia Diatchenko / Alexandra Panova Kamilla Rakhimova → replaced by Aliona Bolsova / Kamilla Rakhimova