| Competition: | Copa Perú |
| Season: | 2021 |
| Winners: | ADT (2nd title) |
| Promoted: | ADT Alfonso Ugarte |
| League Topscorer: |  Elvis Payé (9) |
| Prevseason: | 2019 |
| Nextseason: | 2022 |
The 2021 Peru Cup season (Spanish; Castilian: Copa Perú 2021), the largest amateur tournament of Peruvian football. The Regional Stage (Spanish; Castilian: Etapa Regional) starts in October, and the National Stage (Spanish; Castilian: Etapa Nacional) starts in November. The winner of the National Stage was promoted to the Liga 1 and the runner-up was promoted to the Liga 2.
The following list shows the teams that qualified for the Regional Stage.
| Department | Team | Location |
|---|---|---|
| — | — | |
| Unión Juventud | Chimbote | |
| Apurímac | Miguel Grau | Abancay |
| Andahuaylas | Andahuaylas | |
| Nacional | Arequipa | |
| Futuro Majes | Arequipa | |
| — | — | |
| Las Palmas | Chota | |
| Deportivo Coremarca | Bambamarca | |
| Atlético Chalaco | Callao | |
| Estrella Azul | Ventanilla | |
| Deportivo Garcilaso | Cusco | |
| UDA | Huancavelica | |
| UNH | Huancavelica | |
| Deportivo Verdecocha | La Unión | |
| Miguel Grau UDH | Huánuco | |
| Octavio Espinosa | Ica | |
| Unión San Martín | Pisco | |
| ADT | Tarma | |
| La Libertad | Real Sociedad | Sánchez Carrión |
| Racing | Sánchez Carrión | |
| Department | Team | Location |
|---|---|---|
| Los Caimanes | Puerto Etén | |
| Estudiantes de Túcume | Túcume | |
| DIM | Miraflores | |
| Los Ángeles Negros | Canta | |
| Maristas | Huacho | |
| Defensor Laure Sur | Chancay | |
| Nihue Rao | Iquitos | |
| Athletico Maldonado | Tambopata | |
| Moquegua | ||
| — | — | |
| UDP | Sechura | |
| Juventud Cautivo | Piura | |
| Alfonso Ugarte | Puno | |
| Credicoop San Román | Juliaca | |
| — | — | |
| — | — | |
| Renovación Pacífico | Tumbes | |
| Ucayali | Colegio Comercio | Callería |
| Estudiantes de Economía | Manantay |
The round was played between 3 October and 6 October, on a home-and-away two-legged tie.|-|}
The round was played on 10 October 2021, in a single knock-out match format.|-|-|}
The round was played on 14 October 2021, in a single knock-out match format.|}
| Rank | Name | Club | Goals | ||
|---|---|---|---|---|---|
| align=center | 1 | Elvis Payé | Alfonso Ugarte | align=center | 9 |
| align=center | 2 | Pierre Orosco | Los Caimanes | align=center | 6 |
| align=center | 3 | Yerzon Martínez | UDP Las Palmas | align=center | 6 |
| align=center | 4 | Anthony Cuno | Maristas Futuro Majes | align=center | 5 |
| align=center | 5 | Saúl Reyes | Alfonso Ugarte | align=center | 5 |
| align=center | 6 | Manuel Olaya | Alfonso Ugarte | align=center | 5 |
| align=center | 7 | Jankarlo Chirinos | Credicoop San Cristóbal | align=center | 5 |
| align=center | 8 | Guillermo Vernal | Alfonso Ugarte | align=center | 5 |