| Champ: |  Wang Xinyu Zheng Saisai |
| Runner: | Dalila Jakupović  Nuria Párrizas Díaz |
| Score: | 6–1, 6–1 |
| Edition: | 1st |
| After Name: | Columbus Challenger – Women's doubles |
See main article: 2021 Columbus Challenger.
This was the first edition of the women's event.[1]
Wang Xinyu and Zheng Saisai won the title, defeating Dalila Jakupović and Nuria Párrizas Díaz in the final, 6–1, 6–1.
All seeds received a bye into the quarterfinals, along with one other team.