| Year: | 2021 |
| Team: | Columbia Lions |
| Sport: | football |
| Conference: | Ivy League |
| Short Conf: | Ivy |
| Record: | 7–3 |
| Conf Record: | 4–3 |
| Head Coach: | Al Bagnoli |
| Hc Year: | 6th |
| Off Coach: | Mark Fabish |
| Oc Year: | 7th |
| Def Coach: | Paul Ferraro |
| Dc Year: | 6th |
| Stadium: | Robert K. Kraft Field at Lawrence A. Wien Stadium |
| Prev Year: | 2019 |
The 2021 Columbia Lions football team represented Columbia University in the 2021 NCAA Division I FCS football season as a member of the Ivy League. The team was led by sixth-year head coach Al Bagnoli and played its home games at Robert K. Kraft Field at Lawrence A. Wien Stadium. Columbia averaged 5,549 fans per game.