| Sport: | football |
| Year: | 2021 |
| Team: | Colorado Buffaloes |
| Conference: | Pac-12 Conference |
| Division: | South Division |
| Short Conf: | Pac-12 |
| Record: | 4–8 |
| Conf Record: | 3–6 |
| Hc Year: | 2nd |
| Oc Year: | 2nd |
| Dc Year: | 1st |
The 2021 Colorado Buffaloes football team represented the University of Colorado Boulder during the 2021 NCAA Division I FBS football season. The Buffaloes were led by second-year head coach Karl Dorrell. They played their home games on campus at Folsom Field as a member of the South Division of the Pac-12 Conference.
| Name | Title | |
|---|---|---|
| Head coach | ||
| Chris Wilson | Defensive coordinator/ defensive line coach | |
| Offensive coordinator/wide receivers coach | ||
| Pass game coordinator/ quarterbacks coach | ||
| Safeties coach/defensive passing game coordinator | ||
| Tight ends coach | ||
| Running backs coach | ||
| Cornerbacks coach | ||
| Brian Michalowski | Outside linebackers coach | |
| Mitch Rodrigue (fired mid season) | Offensive line coach | |
| Mark Smith | Inside linebackers coach |