| Club: | Náutico |
| Season: | 2021 |
| Chairman: | Edno Melo[1] [2] |
| Manager: |  Hélio dos Anjos Marcelo Chamusca |
| Stadium: | Estádio dos Aflitos |
| League: | Série B |
| League Result: | 8th |
| Cup1: | Pernambucano |
| Cup1 Result: | Champions (23rd title) |
| League Topscorer: | Jean Carlos (11) |
| Season Topscorer: | Jean Carlos and Vinícius (13) |
| Pattern La1: | _nautico21h |
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| Prevseason: | 2020 |
| Nextseason: | 2022 |
The 2021 season was Náutico's 121st season in the club's history.[3] Náutico competed in the Campeonato Pernambucano[4] and Série B.[5]
| Games played | 50 (12 Pernambucano, 38 Série B) |
| Games won | 22 (8 Pernambucano, 14 Série B) |
| Games drawn | 14 (3 Pernambucano, 11 Série B) |
| Games lost | 14 (1 Pernambucano, 13 Série B) |
| Goals scored | 78 |
| Goals conceded | 64 |
| Goal difference | +14 |
| Best results | 5–0 (H) v Central - Pernambucano - 2021.02.27 5–0 (H) v Operário - Série B - 2021.07.02 |
| Worst result | 0–4 (H) v Confiança - Série B - 2021.08.07 |
| Top scorer | Jean Carlos and Vinícius (13) |